Early susceptibility for epileptiform activity in malformed cortex
نویسندگان
چکیده
منابع مشابه
Optogenetic induced epileptiform activity in a model human cortex
BACKGROUND Cortical stimulation plays an important role in the study of epileptic seizures. We present a numerical simulation of stimulation using optogenetic channels expressed by excitatory cells in a mean field model of the human cortex. FINDINGS Depolarising excitatory cells in a patch of model cortex using Channelrhodpsin-2 (ChR2) ion channels, we are able to hyper-excite a normally func...
متن کاملEarly thalamic lesions in patients with sleep-potentiated epileptiform activity.
OBJECTIVE To compare the prevalence and type of early developmental lesions in patients with a clinical presentation consistent with electrical status epilepticus in sleep either with or without prominent sleep-potentiated epileptiform activity (PSPEA). METHODS We performed a case-control study and enrolled patients with 1) clinical features consistent with electrical status epilepticus in sl...
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Epileptiform activity is associated with impairment of brain function even in absence of seizures, as demonstrated by failures in various testing paradigm in presence of hypersynchronous interictal spikes (ISs). Clinical evidence suggests that cognitive deficits might be directly caused by the anomalous activity rather than by its underlying etiology. Indeed, we seek to understand whether ISs i...
متن کاملCorrigendum: Epileptiform activity in the mouse visual cortex interferes with cortical processing in connected areas
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متن کاملVoltage imaging of epileptiform activity in slices from rat piriform cortex: onset and propagation.
The piriform cortex is a temporal lobe structure with a very high seizure susceptibility. To investigate the spatiotemporal characteristics of epileptiform activity, slices of piriform cortex were examined by imaging electrical activity with a voltage-sensitive fluorescent dye. Discharge activity was studied for different sites of stimulation and different planes of slicing along the anterior-p...
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ژورنال
عنوان ژورنال: Epilepsy Research
سال: 2014
ISSN: 0920-1211
DOI: 10.1016/j.eplepsyres.2013.11.021